topogenic

Blobel extended his studies and was able to demonstrate that proteins destined to become transported to other organelles, or that become integrated into different cellular membranes, also contain specific address tags and so-called "topogenic" signals.

The Nobel Prize in Physiology or Medicine 1999 - Presentation Speech 1999

Specific amino acid sequences (topogenic signals) determine whether a protein will pass through a membrane into a particular organelle, become integrated into the membrane, or be exported out of the cell.

Physiology or Medicine for 1999 - Press Release 1999

Furthermore, knowledge about the topogenic signals has increased our understanding of many medically important mechanisms.

Physiology or Medicine for 1999 - Press Release 1999

As a result one can also deduce the structure and topogenic signals of the proteins.

Physiology or Medicine for 1999 - Press Release 1999

Examples of directed transport mediated by topogenic signals.

Physiology or Medicine for 1999 - Press Release 1999

For example, our immune system uses topogenic signals, e.g. in the production of antibodies.

Physiology or Medicine for 1999 - Press Release 1999

"address tags", signal sequences or topogenic signals, which direct the proteins to a correct place within the cell and allow them to cross the membranes of the organelles.

Physiology or Medicine for 1999 - Press Release 1999