Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of several
enzymes that effect thetopology ofDNA , especially ones that relaxsupercoiling
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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When mice receive a dose of the chemotherapy drug irinotecan, which blocks an enzyme, called topoisomerase, that is important to DNA replication, their gut cells begin to die off.
Scientific American 2010
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Drugs used to treat patients who progress following AT treatment can be as high as 20-30%; however, resistance develops rapidly and new agents with different mechanisms of action, such as topoisomerase I inhibitors, are needed to allow novel ways to overcome the problem of drug resistance.
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Chaga contains betulin, a precursor to betulinic acid, which has been shown to inhibit the cancer-promoting enzyme topoisomerase.
Dr. Nalini Chilkov: Six Cancer-Fighting Medicinal Mushrooms Dr. Nalini Chilkov 2012
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Chaga contains betulin, a precursor to betulinic acid, which has been shown to inhibit the cancer-promoting enzyme topoisomerase.
Dr. Nalini Chilkov: Six Cancer-Fighting Medicinal Mushrooms Dr. Nalini Chilkov 2012
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Chaga contains betulin, a precursor to betulinic acid, which has been shown to inhibit the cancer-promoting enzyme topoisomerase.
Dr. Nalini Chilkov: Six Cancer-Fighting Medicinal Mushrooms Dr. Nalini Chilkov 2012
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Chaga contains betulin, a precursor to betulinic acid, which has been shown to inhibit the cancer-promoting enzyme topoisomerase.
Dr. Nalini Chilkov: Six Cancer-Fighting Medicinal Mushrooms Dr. Nalini Chilkov 2012
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DNA topoisomerase V is unique at the moment, just like ykfE was back in 2001.
Nelson vs Mycoplasma: ORFans redux. - The Panda's Thumb 2006
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DNA topoisomerase V is unique at the moment, just like ykfE was back in 2001.
Nelson vs Mycoplasma: ORFans redux. - The Panda's Thumb 2006
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Damage to the DNA is an important part of producing chromosomal instability, and inhibition of DNA topoisomerase II, a DNA repair enzyme, is implicated in the DNA damage which leads to chromosomal instability.
That's another fine mess you've made Jonathan! - The Panda's Thumb 2005
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Vosaroxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis.
unknown title 2011
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