Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of several enzymes that effect the topology of DNA, especially ones that relax supercoiling

Etymologies

Sorry, no etymologies found.

Examples

  • When mice receive a dose of the chemotherapy drug irinotecan, which blocks an enzyme, called topoisomerase, that is important to DNA replication, their gut cells begin to die off.

    Scientific American

  • Drugs used to treat patients who progress following AT treatment can be as high as 20-30%; however, resistance develops rapidly and new agents with different mechanisms of action, such as topoisomerase I inhibitors, are needed to allow novel ways to overcome the problem of drug resistance.

    NKTR-102 Demonstrates Significant Efficacy as Single-Agent in Second- or Third-Line Treatment in Metastatic Breast Cancer Patients - Yahoo! Finance

  • Chaga contains betulin, a precursor to betulinic acid, which has been shown to inhibit the cancer-promoting enzyme topoisomerase.

    Dr. Nalini Chilkov: Six Cancer-Fighting Medicinal Mushrooms

  • DNA topoisomerase V is unique at the moment, just like ykfE was back in 2001.

    Nelson vs Mycoplasma: ORFans redux. - The Panda's Thumb

  • Damage to the DNA is an important part of producing chromosomal instability, and inhibition of DNA topoisomerase II, a DNA repair enzyme, is implicated in the DNA damage which leads to chromosomal instability.

    That's another fine mess you've made Jonathan! - The Panda's Thumb

  • Vosaroxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis.

  • In oncology, NKTR-102, a novel topoisomerase I-inhibitor, is being evaluated in Phase 2 clinical studies for the treatment of breast, ovarian and colorectal cancers.

  • Its anticancer effect is thought to be mediated through multiple mechanisms of action, including the inhibition of cell proliferation, induction of apoptosis programmed cell death, inhibition of angiogenesis, induction of differentiation, and the resensitization of cells that have become resistant to anticancer agents such as platinums, taxanes and topoisomerase II inhibitors.

  • Previously, we identified topoisomerase II beta (TOP2B) as a novel mediator of RA-resistance in APL cell lines.

    Naturejobs - All Jobs

  • These include alkylating agents, particularly temozolomide (Temodar), topoisomerase I poisons (irinotecan [Camptosar], topotecan [Hycamtin]), and cross-linking drugs (platinum, mitomycin C [Mitozytrex, Mutamycin]).

    Medicaid and Medicare

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