Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun The inactive precursor of trypsin, produced by the pancreas and converted to trypsin in the small intestine by enterokinase.
from The Century Dictionary.
- noun A substance excreted by the pancreas which becomes converted during intestinal digestion into trypsin.
- noun A granular substance in the cells of the pancreas which is the antecedent of trypsin.
from the GNU version of the Collaborative International Dictionary of English.
- noun (Physiol.) The antecedent of trypsin, a substance which is contained in the cells of the pancreas and gives rise to the trypsin.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry An
inactive precursor oftrypsin
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun inactive precursor of trypsin; a substance secreted by the pancreas and converted to active trypsin by enterokinase in the small intestine
Etymologies
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Examples
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The intact gland contains an inactive precursor trypsinogen, which is converted into the protein-dissolving enzyme trypsin only by contact with duodenal juice.
OUPblog 2009
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Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
The Edge of Evolution Michael J. Behe 2007
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A remarkable twist to this conventional gene-duplication/sequence-divergence paradigm is the creation of a unique functional antifreeze glycoprotein (AFGP) sequence from partly non-coding DNA in Antarctic notothenioid fish, involving de novo duplications of a 9-nt sequence spanning an exon-intron junction of an ancestral trypsinogen-type protease gene to form a large, highly repetitive (ThrAlaAla)n coding region, and shedding most of the protease gene structure.
Evolutionary Scrap-heap Challenge: Antifreeze Fish Make Sense Out Of Junk DNA - The Panda's Thumb 2007
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Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
The Edge of Evolution Michael J. Behe 2007
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Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
The Edge of Evolution Michael J. Behe 2007
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Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
The Edge of Evolution Michael J. Behe 2007
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Cheng, in 1998, described the evolution of diverse antifreeze proteins in Antarctic fish, one of which was co-opted from a digestive enzyme called trypsinogen.
A Word About Intelligent Design Creationism - The Panda's Thumb 2007
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I found this interesting , not only because of the evolutionary implications, but also because protease zymogens like trypsinogen act as autocatalytic systems in organisms like me and you, Sal: Trypsinogen enters the small intestine, and gets a peptide bond cloven and breaks down into trypsin.
Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb 2006
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Chen et al. demonstrate that an Antifreeze Glycoprotein AFGP gene from the Antarctic notothenioid Dissostichus mawsoni derives from a gene encoding a pancreatic trypsinogen.
Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb 2006
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The trypsinogen system was investigated (with Bode) in great detail by low temperature crystallography, gamma-ray spectroscopy, chemical modification, and molecular dynamics calculations.
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