Definitions
from The Century Dictionary.
- noun A globulin found in potatoes.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
protein found inpotatoes - noun biochemistry The
tuberous sclerosis protein (known as TSC2)
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word tuberin.
Examples
-
PHR proteins have both E3 ubiquitin ligase activity and guanine nucleotide exchange factor (GEF) activity, and can bind to Myc, adenylate cyclase, tuberin, the co-SMAD Medea, and dual leucine zipper kinases (DLKs) known to regulate the p38 MAP Kinase (MAPK) pathway A particularly well-studied PHR protein is RPM-1, which regulates the formation of NMJs by two parallel mechanisms.
-
− / − ASM cell proliferation is dependent upon the lack of tuberin.
PLoS ONE Alerts: New Articles Elena Lesma et al. 2008
-
Anti-EGFR antibody and rapamycin, however, were clearly less efficient than Consistent with the concept that S6K1 activation is PI3K independent in tuberin-deficient cells, Akt1 siRNA did not interfere with S6 phosphorylation, while PTEN phosphorylation in TSC2
PLoS ONE Alerts: New Articles Elena Lesma et al. 2008
-
− / − ASM cell growth is caused by lack of tuberin.
-
To study the correlation between the proliferative role of EGF and tuberin in ASM cells, the full-length wild-type human tuberin was successfully expressed in TSC2
-
The lack of tuberin or hamartin promotes p70S6K activation and S6 phosphorylation, and increased DNA synthesis in cultures of patient
PLoS ONE Alerts: New Articles Elena Lesma et al. 2008
-
A: In wild type cells, activation of either pathways result in the phosphorylation of both RSK1 and Akt that, in turn, are capable of phosphorylating tuberin directly.
-
− / − ASM cells, and the relationship between the lack of tuberin and the dependency on EGF by these cells.
-
Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, et al. (2004) Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR) - independent.
-
The tuberin-dependent phosphorylation of B-raf and p42 / 44 MAPK, the p42 / 44 MAPK-dependent direct phosphorylation of tuberin and that mediated through S6K suggest an interaction between MAPK pathway and tuberin
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.