Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb Present participle of
ubiquitinate .
Etymologies
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Examples
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The virus avoids the protein p53 control function through one of its proteins activating and changing the recognition pattern of a certain cellular E3 enzyme, E6-AP, which is tricked into ubiquitinating the protein p53, which is totally destroyed.
The Nobel Prize in Chemistry 2004 - Information for the Public 2004
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Several recent studies provide compelling support for this hypothesis by demonstrating that treatment of cultured vertebrate cells with mitochondrial damaging agents triggers PINK1 to selectively recruit Parkin to damaged mitochondria, where Parkin acts to promote the autophagic turnover of these mitochondria, presumably by ubiquitinating particular mitochondrial targets
PLoS ONE Alerts: New Articles Angela C. Poole et al. 2010
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More information: "The Angelman Syndrome-associated ubiquitin ligase Ube3A regulates synapse development by ubiquitinating Arc", Cell, March 5, 2010, Vol 140, No. 5
PhysOrg.com - latest science and technology news stories PhysOrg Team 2010
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a relatively small number of ubiquitin ligases (E3) must be capable of ubiquitinating an assortment of substrates diverse in both structure and location (ER lumen, membrane, and/or cytosol).
Journal of Biological Chemistry current issue Corcoran, K., Wang, X., Lybarger, L. 2009
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