Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The
modification of aprotein by thecovalent attachment of one or moreubiquitin molecules
Etymologies
Sorry, no etymologies found.
Examples
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Are you claiming that ubiquitination is specific for lysine residues, or are you predicting that as a hypothesis that you are interested in testing?
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Are you claiming that ubiquitination is specific for lysine residues, or are you predicting that as a hypothesis that you are interested in testing?
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Interestingly, the ligase involved in BSA ubiquitination is E3a that was discovered during my graduate studies.
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This subject has evolved in a surprising manner and changed another paradigm in the field that ubiquitination is limited to internal lysine (s) of the target substrate; we, and later others, have shown that the phenomenon is not limited to the one protein we identified initially - the muscle-specific transcriptional regulator
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We continued and demonstrated that, unlike the paradigm in the field until that time, that degradation of proteins in the lysosome proceeds independently from the ubiquitin system - the two proteolytic pathways are actually linked to one another, and ubiquitination is required for stress-induced lysosomal degradation of cellular proteins.
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This is typically managed through the process called ubiquitination, in which doomed proteins are chemically marked for entry into a degradation pathway by protein complexes known as ubiquitin ligases.
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This process, called ubiquitination, flags protein substrates for destruction but can also serve as a regulatory signal.
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A while ago I had noticed that prediction of phosphorylation propensity could also predict ubiquitination and vice-versa.
Reply: On the evolution of protein length and phosphorylation sites
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A while ago I had noticed that prediction of phosphorylation propensity could also predict ubiquitination and vice-versa.
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In order to get there I will try first to develop some methods to predict ubiquitination and E3 targets.
Comments
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