Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb Simple past tense and past participle of
ubiquitylate . - adjective biochemistry
ubiquitinated
Etymologies
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Examples
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Accumulation of ubiquitylated protein aggregates can occur during normal human brain ageing and reaches pathological levels in neurodegenerative disorders such as Alzheimer's disease and tauopathies.
Naturejobs - All Jobs Nicholas A. Bishop 2010
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In autophagy-deficient flies and mice, neurodegeneration is accompanied by the accumulation of ubiquitylated protein aggregates, similar to those observed in human neurodegenerative disorders such as Huntington's disease and Alzheimer's disease.
Naturejobs - All Jobs Nicholas A. Bishop 2010
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A new method for producing ubiquitylated proteins developed by Zhuang and his group recently was reported in the prestigious journal
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However, preparing sufficient samples of ubiquitylated proteins for study has been a major challenge facing scientists.
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The new method for developing ubiquitylated proteins, which Zhuang and his team developed, combines the power of intein chemistry and disulfide crosslinking to bond ubiquitin to another essential protein called proliferating cell nuclear antigen.
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A new method for producing ubiquitylated proteins developed by Zhuang and his group recently was reported in the prestigious journal
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Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway
Naturejobs - All Jobs Michael Lammers 2010
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Developed by Zhihao Zhuang, UD assistant professor of chemistry and biochemistry, and his research group, the chemical method yields hundredsfold more ubiquitylated proteins than current approaches.
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Strikingly, in response to transcription-blocking DNA damage, Rpb1, the largest subunit of Pol II, is ubiquitylated and subsequently degraded
PLoS ONE Alerts: New Articles Xuefeng Chen et al. 2009
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In response to UV-induced DNA damage, Rpb1, the largest subunit of Pol II, is ubiquitylated and subsequently degraded in both human and yeast cells
PLoS ONE Alerts: New Articles Xuefeng Chen et al. 2009
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