from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Having no ligand; especially (of a protein) deprived of any small molecule that it is sometimes associated with


Sorry, no etymologies found.


  • It was interesting that the GHSR antagonist JMV3002 did not modify the spontaneous activity of GHRH neurons, suggesting that ghrelin responsiveness may normally require acute activation, and arguing against a constitutive activity of unliganded GHSR

    PLoS ONE Alerts: New Articles

  • Although the kinetic stability of unliganded dimers was in principle sufficient for EGF-independent activation, ligand binding was still required for signalling.

    Naturejobs - All Jobs

  • (Ph) BirA exists as a dimer in both the liganded and unliganded forms

    PLoS ONE Alerts: New Articles

  • Though, Mtb-BirA packs as a dimer in the asymmetric unit of the crystal, it exists as a monomer in the unliganded as well as liganded forms in solution

    PLoS ONE Alerts: New Articles

  • TACC1 interacts preferentially with unliganded NRs.

    BioMed Central - Latest articles

  • Under this hypothesis, the absence of Eda that leads to a pathway containing an "active" unliganded Edar will lead to a different phenotype than the loss of

    PLoS ONE Alerts: New Articles

  • Davis MG, Howard BW, Pokross M, Rastogi V, et al. (2003) Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component.

    PLoS ONE Alerts: New Articles

  • From these measurements we calculated all of the equilibrium constants of the "allosteric" cycle as follows: diliganded gating, unliganded gating, dissociation from the C (losed) conformation, and dissociation from the O (pen) conformation.

    Journal of Biological Chemistry current issue

  • Interestingly, the corresponding loop in MvNei1 is ordered in both the unliganded and furan-bound structures, unlike other Fpg/Nei enzymes where the loop is generally ordered in the unliganded enzyme or in complexes with a lesion, and disordered otherwise.

    Journal of Biological Chemistry current issue

  • Nei, where a dramatic conformational change was observed upon binding DNA, the structure of MvNei1 bound to DNA does not reveal any substantial movement compared with the unliganded enzyme.

    Journal of Biological Chemistry current issue


Log in or sign up to get involved in the conversation. It's quick and easy.