Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Not methylated

Etymologies

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Examples

  • Methylated CpGs are presented by black circles and unmethylated sites by open circles.

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  • Bernstein E, Li K, Jia D, et al. (2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.

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  • Though Pol II stalling at the HoxC6 and HoxC8 genes involves DNA methylation, clearly not all Pol II stalling is attributed to DNA methylation and Pol II stalling is found at unmethylated promoter regions

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  • Human glioblastoma cells (GBM43) with an unmethylated

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  • Since the salmonids lack TLR-2, it might therefore be suggested that TLR-3 and 9 in these species could have a similar role as TLR-2 in the mammals, where this receptor is also a sensor of necrotic cells, while TLR-9 in the mammals recognises bacterial and viral DNA, unmethylated CpG and DNA without CpG motifs

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  • Using murine models of invasive aspergillosis, Bozza et al have shown that intranasal delivery of Asp f9 (reported as Asp f16) with unmethylated CpG oligodeoxynucleotides induces protective T

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  • This patient trial is specifically designed for those whose tumor cells have "unmethylated MGMT promoter."

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  • For instance, the dissemination of antibiotic resistance genes, as well as the uncontrolled expression of backbone sequences in patients may have profound detrimental effects and unmethylated bacterial CpG motifs have been shown to contribute to silencing of transgene expression.

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  • Fully unmethylated and fully Sssl-methylated DNA were employed initially as 0 and 100% methylated references to test amplification results, and methylated DNA was further used as calibrator for all tested samples.

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  • This procedure integrated the DNA denaturation and bisulfite conversion into one-step, using temperature denaturation to replace chemical denaturation with sodium hydroxide, and it was based on a three-step reaction process between cytosine and sodium bisulfite that converts unmethylated cytosines into uracils.

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