from Wiktionary, Creative Commons Attribution/Share-Alike License

  • v. Present participle of up-regulate.


Sorry, no etymologies found.


  • "The rapidly aging mice switched their activity from growth to maintenance and repair, up-regulating cellular defenses and down-regulating respiration and metabolism," Hoeijmakers says.

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  • Most amazingly, in recent years several natural substances such as pterostilbene from blueberries have demonstrated a wide range of positive effects on gene expression, up-regulating many disease-protective, antiaging genetic functions.

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  • Cinnamon extract strongly inhibited tumor cell proliferation in vitro and induced active cell death of tumor cells by up-regulating pro-apoptotic molecules while inhibiting NFB and

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  • Kroll TG, Allard P, Ye K (2004) Pike-a is amplified in human cancers and prevents apoptosis by up-regulating akt.

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  • Many studies have suggested that, just as with any drug addiction, the brain strives to return to its normal function while under "attack" from caffeine by up-regulating, or creating more adenosine receptors.


  • This can cause cancer by up-regulating genes for cell division or by down-regulating tumour suppressor genes.

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  • This family of proteins can protect against the damage by increasing the concentration of antioxidants within cells and by up-regulating proteins that repair the damage done by reactive oxidative species.

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  • Cells up-regulating ZEB1 in the ischemic cortex co-localize with the neuronal marker NeuN.

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  • Its genes are no longer producing proteins, so neo-X has to compensate by up-regulating its genes.

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  • It is interesting to note however that in our transcriptional analysis there seemed to be a stronger up-regulating response in the males compared to the females, despite the history of male resilience to environmental dietary alteration.

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