Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • v. To increase the number of cell receptors by using upregulation.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From up- +‎ regulate.

Examples

  • "upregulate," or churn out, genes that make molecules that signal the immune system to throttle back; and they can "downregulate," or reduce the production of, genes that make molecules that carry signals between immune cells.

    Vaccinating Against Cancer

  • When phytonutrients and other molecules that contain the Michael acceptor–like pharmacophore upregulate the transcription factor NRF2, more than a dozen protective anti-inflammatory proteins in the cell are activated.

    Forever Young

  • Upon activation, these transcription factors translocate to the nucleus of the cell, where they attach to receptor sites on the genes and upregulate, or turn on, their expression.

    Forever Young

  • These in turn upregulate negative genes that produce pro-inflammatory cytokines that damage skin cells.

    Forever Young

  • When applied topically, they function as a powerful anti-inflammatory agent, partially because of their ability to upregulate NRF2, which provides the skin with many benefits, including increased radiance, decreased pore size, and, with continued use, a reduction in fine lines and discolorations.

    Forever Young

  • At the same time, the molecules that we thought were just antioxidants bind to and turn off transcription factors that are known to upregulate more than a hundred inflammation-generating genes, resulting in damage to all of our organ systems.

    Forever Young

  • We now know that many of these phytonutrients also work through other mechanisms, specifically the expression of genes that can upregulate the natural protective mechanisms of our cells.

    Forever Young

  • As a dermatologist, I have been delighted to learn that when these nutrients are applied topically, they can upregulate the expression of genes that decrease and/or prevent inflammation.

    Forever Young

  • When these nutrients upregulate gene expression, the following benefits result:

    Forever Young

  • This flow activates sensors on the left rather than the right, that upregulate nodal expression.

    The Panda's Thumb: Development Archives

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