Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb Third-person singular simple present indicative form of
upregulate .
Etymologies
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Examples
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11 When COX-2 is induced during the inflammatory response, increased prostaglandin expression upregulates various inflammation mediators and regulates the formation and activities of osteoblasts and osteoclasts.
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By acting as a mild oxidizing agent, they activate the protective transcription factor NRF2, which then upregulates a multitude of cell-protective enzymes and molecules.
Forever Young M.D. Nicholas Perricone 2010
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This anti-inflammatory signaling agent upregulates the expression of a gene that encodes for a cell-protective substance called heme oxygenase 1 HO-1.
Forever Young M.D. Nicholas Perricone 2010
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"This is one of the major human tumor suppressor proteins, and it's clear that the naked mole rat has that protein and upregulates it more rapidly in certain situations that probably prevent cancer formation," Enders said.
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In plants, pathogen infection upregulates expression of PR genes
PLoS ONE Alerts: New Articles Chang-Jin Park et al. 2010
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Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, et al. (2005) Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.
PLoS ONE Alerts: New Articles Donald Courter et al. 2010
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In plants, pathogen infection upregulates expression of PR genes
PLoS ONE Alerts: New Articles Chang-Jin Park et al. 2010
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Hennig B, Neish AS, Toborek M (2001) IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells.
PLoS ONE Alerts: New Articles Anil K. Singh et al. 2010
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Sallette J, Pons S, Devillers-Thiery A, Soudant M, Prado de Carvalho L, et al. (2005) Nicotine upregulates its own receptors through enhanced intracellular maturation.
PLoS ONE Alerts: New Articles Nyresa C. Alves et al. 2010
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Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, et al. (2007) Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.
PLoS ONE Alerts: New Articles Nyresa C. Alves et al. 2010
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