from Wiktionary, Creative Commons Attribution/Share-Alike License

  • v. Third-person singular simple present indicative form of upregulate.


Sorry, no etymologies found.


  • 11 When COX-2 is induced during the inflammatory response, increased prostaglandin expression upregulates various inflammation mediators and regulates the formation and activities of osteoblasts and osteoclasts.

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  • By acting as a mild oxidizing agent, they activate the protective transcription factor NRF2, which then upregulates a multitude of cell-protective enzymes and molecules.

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  • This anti-inflammatory signaling agent upregulates the expression of a gene that encodes for a cell-protective substance called heme oxygenase 1 HO-1.

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  • "This is one of the major human tumor suppressor proteins, and it's clear that the naked mole rat has that protein and upregulates it more rapidly in certain situations that probably prevent cancer formation," Enders said.

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  • In plants, pathogen infection upregulates expression of PR genes

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  • Sallette J, Pons S, Devillers-Thiery A, Soudant M, Prado de Carvalho L, et al. (2005) Nicotine upregulates its own receptors through enhanced intracellular maturation.

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  • Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, et al. (2007) Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.

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  • Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, et al. (2005) Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.

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  • Hennig B, Neish AS, Toborek M (2001) IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells.

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  • Our Hemoflow matrix does this using a few very common herbal extracts and thus strongly upregulates the effectiveness of all the other ingredients in the HemoDrene ™ formula.

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