Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. urate oxidase, an enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate.

Etymologies

Sorry, no etymologies found.

Examples

  • A number of catabolic enzymes were known: nucleases, nucleotidases, nucleosidases, deaminases (for guanine, adenine, adenosine, and adenylic acid), xanthine oxidase and uricase.

    Nobel Lecture The Purine Path To Chemotherapy

  • Duke developed the recombinant uricase enzyme and MVP developed the PEGylation technology used in the manufacture of KRYSTEXXA.

    Savient Pharmaceuticals Provides Business Update - Yahoo! Finance

  • The uricase enzyme in Krystexxa allows us to processes uric acid - which has relatively low solubility in water - into allantoin - which has relatively high solubility.

    SeekingAlpha.com: Home Page

  • The uricase enzyme is pegylated - a chemical modification in which polyethylene glycol is affixed to the surface of the enzyme.

    SeekingAlpha.com: Home Page

  • Krystexxa is actually just uricase, an enzyme that is found in virtually all mammals besides humans and some apes.

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  • In their review of uric acid and cardiovascular disease, Feig and colleagues (Oct. 23 issue) 1 state that "it is worth noting that humans and apes have higher uric acid levels than most other mammals, since they lack the hepatic enzyme uricase, which degrades uric acid to allantoin."

    Medlogs - Recent stories

  • The uricase gene underwent mutational silencing during hominoid evolution in the Miocene epoch some 8 million to 24 million years ago, an event that was postulated to confer

    Medlogs - Recent stories

  • KRYSTEXXA (TM) (pegloticase) is a PEGylated uricase enzyme intended for the treatment of chronic gout in patients refractory to conventional therapy.

    Medlogs - Recent stories

  • Savient has developed one product: KRYSTEXXA (TM) (pegloticase) which is a PEGylated uricase enzyme intended for the treatment of chronic gout in patients refractory to conventional therapy.

    Medlogs - Recent stories

  • It was noted in 1970 that the inability of higher primates to break down uricase, parallels the well-known metabolic disease of higher primates.

    Citizendium, the Citizens' Compendium - Recent changes [en]

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