from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A sudden constriction of a blood vessel, causing a reduction in blood flow.
from The Century Dictionary.
- noun Spasmodic contraction of the blood-vessels.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
Spasmof the blood vessels, leading to vasoconstrictionand potentially tissue ischemiaand necrosis.
from Wiktionary, Creative Commons Attribution/Share-Alike License
Treatments available today are only minimally effective because the doses that can be tolerated by patients are too low to prevent certain types of delayed complications such as vasospasm, a type of stroke that is a leading cause of permanent brain damage or death after brain injury, "said Dr. Macdonald.
Cocaine can produce death in rare instances, usually from coronary artery vasospasm, and sometimes even from a stroke.
NimoGel is delivered directly to the site in the brain where it is needed, thus providing very high drug concentrations at the specific site at risk for life-threatening vasospasm while using 80% less drug than is currently administered systemically.
And new research suggests that MgSO4 infusions may have a role in cerebral vasospasm prophylaxis if therapy is initiated within 48 hours of aneurysm rupture.
Cerebral vasospasm is a leading delayed complication following aneurysmal subarachnoid hemorrhage or TBI.
NimoGel ™ is designed to be placed directly next to brain arteries after ruptured brain aneurysms or TBI to prevent vasospasm, a type of secondary stroke, and thereby improve patient outcomes.
To this end, we present a systematic review of 21 studies suggesting a genetic basis for clinical outcome after aSAH, with a special emphasis on the pathogenesis of cerebral vasospasm and delayed cerebral ischemia.
"This is a new observation indicating a role for Pycnogenol for both kidney function protection and a specific reduction in the diffuse vasospasm present in participants at the kidney level," they added.
Far less work has centered on the genetic determinants of cerebral vasospasm, the predisposition to delayed cerebral injury, and the determinants of ensuing functional outcome after aSAH.
"The NimoGel clinical development program is important because it has the potential to deliver high enough concentrations of nimodipine to the brain to prevent vasospasm and avoid the systemic side effects caused by oral nimodipine."