Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A membrane-cytoskeletal protein in focal adhesion plaques, involved in linkage of integrin adhesion molecules to the actin cytoskeleton

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

vinculum +‎ -in

Examples

  • Talin binds vinculin and integrins. talin is a substrate for the Ca2+-activated protease calpain II.

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  • Building on earlier studies, Mofrad's team developed a detailed model demonstrating that, when a cell experiences force, focal adhesion proteins such as talin and vinculin change molecular shape.

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  • Focal adhesion kinase-dependent regulation of adhesive force involves vinculin recruitment to focal adhesions.

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  • Focal adhesion area was computed by tracing the vinculin stained regions.

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  • Immunohistochemical staining for vinculin in an un-stretched cell. b, Immunohistochemical staining for vinculin immediately after a single transient biaxial stretch (

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  • At the earliest time point following a 10\% uniform transient stretch, cells were fixed with 5\% formalin for 10 min, permeabilized for 5 min with 0. 5\% Triton X-100 (Sigma-Aldrich), blocked with a solution containing 5\% goat serum and 1\% BSA and subsequently stored overnight with a primary antibody directed against vinculin (V9131 monoclonal antivinculin antibody,

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