viscerotropic

DoD is continuing its work as a world leader in developing a less invasive test for viscerotropic leishmaniasis that may provide for broader diagnostic screening in the future.

Fact Sheet On Initiatives On Gulf War Illnesses ITY National Archives 1997

It was considered that the loss of both the viscerotropic as well as neurotropic affinities as demonstrated in monkeys made this the virus of choice for human vaccination.

Max Theiler - Nobel Lecture 1964

While it was plain that the viscerotropic affinity could be readily reduced either by mouse brain passage or by prolonged tissue culture, what was particularly desired was a method of reducing the neurotropism.

Max Theiler - Nobel Lecture 1964

In the culture experiments, attempts were made to propagate the virus in as wide a variety of tissues as possible, in the hope that in one the desired attenuation of both the viscerotropic as well as the neurotropic affinities would occur.

Max Theiler - Nobel Lecture 1964

The culture experiments to date had shown that the viscerotropic affinity of the Asibi strain could be readily reduced without at the same time producing a change in the neurotropic affinity.

Max Theiler - Nobel Lecture 1964

The French viscerotropic virus was cultured for several hundred subcultures in three different media, the tissue component of which consisted of, respectively, mouse-embryo brain, minced whole-chick embryo, and minced chick-embryo containing minimal amounts of nervous tissue.

Max Theiler - Nobel Lecture 1964

In conclusion, we may summarize the culture experiments by stating that any yellow fever virus maintained in tissue culture will become attenuated somewhat in its viscerotropic affinities, irrespective of the tissue used.

Max Theiler - Nobel Lecture 1964

The Asibi virus with which all these culture experiments were undertaken is highly pathogenic, not only for monkeys by parenteral inoculation but also for mice by intracerebral inoculation; that is, its viscerotropic as well as its neurotropic affinities are highly developed.

Max Theiler - Nobel Lecture 1964

Numerous attempts to cultivate strains of yellow fever virus with low viscerotropic or neurotropic affinities at first ended in failure.

Max Theiler - Nobel Lecture 1964