from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A particular drug used to treat cancer.


Sorry, no etymologies found.


  • Paul Marks and Ronald Breslow at Columbia created a small molecule, called vorinostat, that blocks the action of the enzymes that tamper with DNA's packaging, thus turning inactivated genes back on.

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  • The data in the publication in the British Journal of Cancer suggest that sapacitabine given in combination with HDAC inhibitors, such as vorinostat or sodium valproate, results in significantly enhanced cell death in AML cells and cell lines derived from other tumor tissues, including cutaneous T-cell lymphoma (CTCL), non-Hodgkins lymphoma (NHL) and non-small cell lung cancer (NSCLC).

    Publications Highlight Novel Combinations of Sapacitabine With Targeted Agents for the Treatment of Cancer - Yahoo! Finance

  • As a reference standard for the comparison of results, we used suberoylamide hydroxamic acid (SAHA; also referred to as "vorinostat"), a non-specific inhibitor of both classes of HDACs when used in the upper-nanomolar/micromolar range of concentrations [15].

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  • The U.S. Food and Drug Administration (FDA) has approved Zolinza (vorinostat) capsules for the treat ...


  • Results from two investigational Phase I trials of ZOLINZA (vorinostat) in combination with bortezom ...


  • Co. 's vorinostat, a treatment for T-cell lymphoma and the only FDA-approved drug that targets acetylation-modifying enzymes, faced challenges because of poor selectivity, Schreiber notes.

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  • Results from two Phase 1 studies of ZOLINZA (vorinostat), Merck's oral histone deacetylase (HDAC) in ...


  • Measurement of the HDAC isoform selectivity profile of sodium valproate, sodium butyrate, and vorinostat revealed the common inhibition of class I HDACs

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  • (HDAC1, 2, 3, 8) with little effect on the class IIa HDAC family members (HDAC4, 5, 7, 9) and inhibition of HDAC6 only by vorinostat.

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  • Injections of sodium valproate, sodium butyrate, or vorinostat (suberoylanilide hydroxamic acid; Zolinza®) completely restored contextual memory in these mutant mice.

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