Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A furanosteroid metabolite of the fungus Penicillium funiculosum; it is an inhibitor of some kinases

Etymologies

Sorry, no etymologies found.

Examples

  • Inhibition of PI 3-kinase with wortmannin is associated with inhibition of insulin stimulated Glu uptake and synthesis of glycogen, lipid, and protein Regulatory Catalytic

    Recently Uploaded Slideshows

  • In wild-type mice, wortmannin or peptide competition attenuated the sensitization.

    Naturejobs - All Jobs

  • (1% FCS) medium were treated with canonical Wnt3a (15% CM) for 24 hours in the presence or absence of the MEK inhibitor U0126 or the PI3k inhibitor wortmannin, and effector caspase activity was determined.

    PLoS ONE Alerts: New Articles

  • [3H] myo inositol for 24 h and then pre-treated with 100 nM wortmannin for 15 min before stimulation with 100 ng/ml FGF-2.

    PLoS ONE Alerts: New Articles

  • After 24 h cells were serum deprived overnight in M199+0. 5% FBS and then left untreated or pre-treated with 100 nM wortmannin for 15 min before stimulation with 100 ng/ml FGF-2 for 10 min.

    PLoS ONE Alerts: New Articles

  • B, PDK1 phosphorylation induced by ghrelin (100 nM, 5 min) in the absence or presence of PTX (100 ng / mL, 12 h) and the PI3K inhibitor wortmannin (1 µM, 30 min).

    PLoS ONE Alerts: New Articles

  • Similar results were obtained using the irreversible PI3K inhibitor wortmannin (Figure S2).

    PLoS ONE Alerts: New Articles

  • Ghrelin-induced Akt phosphorylation in the absence or presence of PTX (100 ng / mL, 12 h), PI3K inhibitor wortmannin (1 µM, 30 min) and βγ sequester β-ARK-CT.

    PLoS ONE Alerts: New Articles

  • Recombinant human Sfrp1 was from R&D, Minneapolis, MN, USA, and blocking N-cadherin antibody and pharmacologic inhibitors of PI3K (wortmannin) and MEK (U0126) were from Sigma (USA).

    PLoS ONE Alerts: New Articles

  • − / − ASM cells and those virally transfected with TSC2 gene; however, PI3K inhibitors, such as LY294002 and wortmannin, were able to affect this process only in TSC2-transfected cells.

    PLoS ONE Alerts: New Articles

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.