Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An anticoagulant drug once proposed as a replacement for warfarin but withdrawn due to hepatotoxicity risks.
Etymologies
Sorry, no etymologies found.
Examples
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An AstraZeneca PLC drug called ximelagatran came close, but failed when it proved toxic to the liver.
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I had my hopes that ximelagatran would be the replacement for warfarin.
This time,new oral anticoagulants may well make it to the market
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Lincoff told heartwire that, undoubtedly, hangovers from the ximelagatran experience were making people nervous.
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The signal with ximelagatran "was clearly more frequent than any potential signal we are dealing with here, but the FDA wanted to be cautious," Lincoff notes.
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The experience with ximelagatran had indicated that monotherapy with the drug was associated with higher early rates of recurrent VTE relative to warfarin, Schulman and colleagues wrote.
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The researchers said no liver toxicity was seen with the drug, in contrast to another oral thrombin inhibitor, ximelagatran.
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"We know that with warfarin and, to some extent, direct thrombin inhibitors like ximelagatran, more potent anticoagulation can reduce those events, but, as with all effective anticoagulants, they increase bleeding."
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