zimelidine

Some six years later, S. B. Ross and associates found a powerful member of this class of substances called zimelidine.

Alcohol and The Addictive Brain Kenneth Blum 1991

Some six years later, S. B. Ross and associates found a powerful member of this class of substances called zimelidine.

Alcohol and The Addictive Brain Kenneth Blum 1991

Carlsson knew better because he had invented the first SSRI, zimelidine, which the Swedish pharmaceutical company Astra brought to market as an antidepressant named Zelmid in 1982, five years before Prozac.

MANUFACTURING DEPRESSION Gary Greenberg 2010

By 1971, he and his team had come up with zimelidine Zelmid, the first drug designed specifically to inhibit serotonin reuptake.

MANUFACTURING DEPRESSION Gary Greenberg 2010

But in 1983, just as the process was getting under way, trouble arose in Europe: zimelidine syndrome, a flu-like condition, and, more ominously, an outbreak of Guillain-Barré syndrome, a sometimes fatal neurological disorder, among users.

MANUFACTURING DEPRESSION Gary Greenberg 2010

But in the meantime, Astra, spurred on by Carlsson, was taking zimelidine through clinical trials in Sweden.

MANUFACTURING DEPRESSION Gary Greenberg 2010

The first is that zimelidine acts in the brain to reduce craving.

Alcohol and The Addictive Brain Kenneth Blum 1991

Later, Naranjo would find a drug called citralopam that also increases the availability of serotonin at the synapse and reduces craving, with fewer side effects than zimelidine.

Alcohol and The Addictive Brain Kenneth Blum 1991

Those who took zimelidine showed a small decrease in alcohol consumption, but a marked increase in the number of days of complete abstinence.

Alcohol and The Addictive Brain Kenneth Blum 1991

Although zimelidine appears to have possible applications as an anticraving agent, its side effects pose serious problems.

Alcohol and The Addictive Brain Kenneth Blum 1991