Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun Any salt or ester of zoledronic acid

Etymologies

Sorry, no etymologies found.

Examples

  • Zoledronic acid, also known as zoledronate, is used to prevent bone fractures in patients with cancers like prostate cancer and multiple myeloma, or for treatment of bone metastases.

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  • N-BPs, such as zoledronate, acted on the mevalonate pathway inhibiting the farnesyl diphosphate synthase (FPP) thereby depleting the cells of the farnesyl (FPP) or geranylgeranyl (GGPP) diphosphate isoprenoids

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  • When used in combination with hormone therapy in a recent clinical trial, the bisphosphonate drug zoledronate significantly reduced the recurrence of breast cancer in premenopausal women with estrogen-receptor-positive breast cancer.

    New Anti-cancer Drug | Impact Lab

  • But zoledronate quickly binds to bone, reducing its efficacy in other tissues.

    New Anti-cancer Drug | Impact Lab

  • In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells.

    New Anti-cancer Drug | Impact Lab

  • In addition, the efficacy of zoledronate on bone metastasis seems to be supported by its affinity for osseous tissues rather than its direct antiproliferative effect on tumor cells

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  • Furthermore, no pre-clinical works demonstrated an antiproliferative effect of zoledronate on primary breast tumor growth in nude mice.

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  • In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer:

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  • Also, zoledronate was a compound rapidly eliminated from plasma, resulting in renal excretion, rapid bone or calcified tissues uptake and accumulation partly due to its phosphonic functions.

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  • The only study demonstrating an inhibition effect of zoledronate on primary tumor growth used mesothelioma tumors which involved calcification that could uptake the drug

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