Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Variant of roentgen.

Etymologies

Sorry, no etymologies found.

Examples

  • Seliciclib is an inhibitor of cyclin-dependent kinases [CDKs], such as CDK2, CDK7 and CDK9.

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  • The authors suggest that the functional role of the aberrant CDK2 transcript is an attractive target of future investigation.

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  • A particularly interesting finding was that a recurrent chimeric transcript was found involving the CDK2 gene, known to be required for melanoma cell proliferation.

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  • After confirming that the LMW forms of cyclin E suppress the anti-proliferative effects of letrozole, the researchers examined whether a CDK2 inhibitor could reverse the drug resistance in the unresponsive breast cancer cells.

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  • Keyomarsi noted that these patients can be treated with a CDK2 inhibitor, which is now clinically available.

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  • PD-03322991 was specifically associated with attenuation of CDK2 inhibitors, indicating that redundancy in CDK functions represents a determinant of therapeutic failure.

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  • However, their research also showed that treating breast cancer cells with a cyclin-dependent kinase 2 (CDK2) inhibitor can reverse letrozole resistance.

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  • "We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said.

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  • MiTF also controls the expression of Tbx2 and CDK2, which are involved in melanoma proliferation and suppression of senescence All work with mice was carried out in adherence to French Government guidelines as well as those of the NIH and was approved by the Pierre et Marie Curie University.

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  • Horstmann MA, Ramaswamy S, Ross K, et al. (2004) Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.

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