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Examples
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Seliciclib is an inhibitor of cyclin-dependent kinases [CDKs], such as CDK2, CDK7 and CDK9.
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However, their research also showed that treating breast cancer cells with a cyclin-dependent kinase 2 (CDK2) inhibitor can reverse letrozole resistance.
THE MEDICAL NEWS Editors 2010
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However, their research also showed that treating breast cancer cells with a cyclin-dependent kinase 2 (CDK2) inhibitor can reverse letrozole resistance.
PhysOrg.com - latest science and technology news stories 2010
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"We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said.
PhysOrg.com - latest science and technology news stories 2010
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PD-03322991 was specifically associated with attenuation of CDK2 inhibitors, indicating that redundancy in CDK functions represents a determinant of therapeutic failure.
Naturejobs - All Jobs J L Dean 2010
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After confirming that the LMW forms of cyclin E suppress the anti-proliferative effects of letrozole, the researchers examined whether a CDK2 inhibitor could reverse the drug resistance in the unresponsive breast cancer cells.
THE MEDICAL NEWS Editors 2010
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The authors suggest that the functional role of the aberrant CDK2 transcript is an attractive target of future investigation.
PhysOrg.com - latest science and technology news stories 2010
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"We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said.
THE MEDICAL NEWS Editors 2010
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A particularly interesting finding was that a recurrent chimeric transcript was found involving the CDK2 gene, known to be required for melanoma cell proliferation.
PhysOrg.com - latest science and technology news stories 2010
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Keyomarsi noted that these patients can be treated with a CDK2 inhibitor, which is now clinically available.
THE MEDICAL NEWS Editors 2010
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