Optineurin

Optineurin has been shown to be present in the native RGCs in mouse eyes

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

The cells were cultured in complete medium as previously described Optineurin expression vectors pTarget-FLAG-wild type optineurin (OPTN) and pOPTN-EGFP, as well as pRab8

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin also interacted with molecules including Rab8, myosin VI, and transferrin receptor to assemble into supermolecular complexes.

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin is ubiquitously expressed in non-ocular tissues such as the heart and brain [8] and in ocular tissues including the retina, trabecular meshwork, and non-pigmented ciliary epithelium Optineurin shares 53% amino acid homology with NEMO (NF-κB essential modulator) and was identified as a NEMO-related protein

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Fetuin was resistant to single O-glycosidase digestion due to the fact that its N-linked and O-linked oligosaccharides are sialylated Optineurin is neither N - (A) nor O - (B) glycosylated but is phosphorylated (C).

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin also interacted with molecules including Rab8, myosin VI, and transferrin receptor to assemble into supermolecular complexes.

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin (OPTN) was detected exclusively in the hydrophilic fraction.

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Sahlender DA, Roberts RC, Arden SD, Spudich G, Taylor MJ, et al. (2005) Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin foci largely did not overlap with the GM130 staining.

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

Optineurin foci have been shown to colocalize, at least partially, with Rab8, myosin VI, and TfR in human RPE cells

PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010