Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • A city of northern Spain on the Bay of Biscay west-northwest of Bilbao. It was a major port after the discovery of America and is now a resort and industrial center.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • proper noun A city and port on the north coast of Spain, the capital of the autonomous community of Cantabria
  • proper noun A department in the north of Colombia. See Wikipedia:Santander Department
  • proper noun A Spanish surname

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

Possibly from the name of Saint Andrew (through a form Sanct Ander) or from Saint Emeterio (through forms Santemter > Santenter > Santander), a martyr whose head was brought there in the third century.

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