acyltransferase love

acyltransferase

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of several transferase enzymes that catalyze the transfer of acyl groups between lipids

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

acyl +‎ transferase

Examples

  • Francone OL (1998) Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin: cholesterol acyltransferase promoter.

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  • (RPE65) or lecithin:retinol acyltransferase (LRAT) that are amenable to intervention with

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  • The Phase 1b trial is a short-term, open-label, single-center study to evaluate the safety profile and effects on retinal function in 8 pediatric subjects (aged 5 to 14 years) diagnosed with LCA due to inherited deficiency of retinal pigment epithelium protein 65 (RPE65) or lecithin: retinol acyltransferase (LRAT).

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  • In a previous study, Monetti et al. [32] report that various lipids, including TG, DAG and ceramides, accumulated in mouse liver as a result of overexpression of acyl-CoA: diacylglycerol acyltransferase (DGAT) but without associated insulin resistance, and they concluded that hepatic steatosis could ensue independently of insulin resistance.

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  • [3] Casaschi A et al, Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.

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  • The Phase 1b trial is a short-term, open-label, single-center study to evaluate the safety profile and effects on retinal function in 8 pediatric subjects (aged 5 to 14 years) diagnosed with LCA due to inherited deficiency of retinal pigment epithelium protein 65 (RPE65) or lecithin: retinol acyltransferase (LRAT).

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  • Chen X, Hyatt BA, Mucenski ML, Mason RJ, Shannon JM (2006) Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells.

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  • In this study, we present the biochemical characterization of a protein serine acyltransferase present in the microsomal fraction of HEL cells, which we have termed ERAT (endoplasmic reticulum O-acyl transferase).

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  • In order to determine whether the human acyltransferase is membrane-bound or soluble, microsomal membranes were extracted with 1

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  • Enzyme preparations were diluted in buffer to achieve a final protein concentration of 0.5 mg / ml and, when present, of Triton X-100 to 0. 03\%, well below the expected inhibitory concentration to the acyltransferase activity (0. 1\% Triton X-100 results in 20\% inhibition; data not shown).

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Comments

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    July 5, 2009