from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A synthetic drug analog of pyrophosphate that acts primarily on bone to inhibit its resorption and is used to treat and prevent osteoporosis in postmenopausal women.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry Any
saltor esterof alendronic acid
- noun medicine The
sodiumsalt of alendronic acid used to treat osteoporosis
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a tablet (trade name Fosamax) prescribed to prevent or treat osteoporosis in women after menopause
from The American Heritage® Dictionary of the English Language, 4th Edition
"Our findings raise the possibility that severe suppression of bone turnover may develop during long-term alendronate therapy, resulting in increased susceptibility to, and delayed healing of, nonspinal fractures."
Long-term alendronate treatment is associated with an increase in the number of osteoclasts, which include distinctive giant, hypernucleated, detached osteoclasts that are undergoing
So for this post, I would like to discuss Fosamax aka alendronate and dentistry, because there is a definitive risk factor involved.
When drugs called bisphosphonates were introduced to prevent and treat osteoporosis Fosamax, now available as a generic called alendronate, was the first, overly enthusiastic doctors prescribed them for millions of postmenopausal women who were not at high risk of fracture.
In a letter in the New England Journal of Medicine, U.S. Food and Drug Administration official Diane Wysowski said that since Fosamax, also known as alendronate, became available in 1995, the FDA has received 23 reports of patients who developed oesophageal tumours, including eight deaths.
"From this study it cannot be concluded that the alendronate was a causal factor in the development of osteonecrosis," says Khan, who has consulted for drug companies including Merck.
In the 150,000-plus cohort of generally healthy postmenopausal women, the researchers found that women who used bisphosphonates, mostly alendronate, which is sold as Fosamax by Merck, had 32 percent fewer cases of invasive breast cancer compared to women who did not use such drugs.
You can help minimize the loss by getting adequate calcium and vitamin D, and taking a bone-building drug such as alendronate (Fosamax and generic) if you have osteoporosis.
You can help minimize the loss by getting adequate calcium and vitamin D, and taking a bone-building drug such as alendronate Fosamax and generic if you have osteoporosis.
Drugs, such as alendronate and raloxifene work by decreasing bone resorption.