Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun A synthetic drug analog of pyrophosphate that acts primarily on bone to inhibit its resorption and is used to treat and prevent osteoporosis in postmenopausal women.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun organic chemistry Any salt or ester of alendronic acid
  • noun medicine The sodium salt of alendronic acid used to treat osteoporosis

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun a tablet (trade name Fosamax) prescribed to prevent or treat osteoporosis in women after menopause

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

Probably a(mino) + (buty)l(id)en(e), a bivalent hydrocarbon radical (butyl + -id(e) + -ene) + (hy)dr(oxy) + (phosph)onate, chemical compound name (phosphon(ium) + -ate2).

Examples

  • "Our findings raise the possibility that severe suppression of bone turnover may develop during long-term alendronate therapy, resulting in increased susceptibility to, and delayed healing of, nonspinal fractures."

    Merck funded and edited article in JAMA--surprise--supports Merck drug

  • Long-term alendronate treatment is associated with an increase in the number of osteoclasts, which include distinctive giant, hypernucleated, detached osteoclasts that are undergoing

    Medlogs - Recent stories

  • So for this post, I would like to discuss Fosamax aka alendronate and dentistry, because there is a definitive risk factor involved.

    Thomas P. Connelly, D.D.S.: Do the Osteoporosis Medicine Fosamax and Dental Work Mix?

  • When drugs called bisphosphonates were introduced to prevent and treat osteoporosis Fosamax, now available as a generic called alendronate, was the first, overly enthusiastic doctors prescribed them for millions of postmenopausal women who were not at high risk of fracture.

    NYT > Home Page

  • In a letter in the New England Journal of Medicine, U.S. Food and Drug Administration official Diane Wysowski said that since Fosamax, also known as alendronate, became available in 1995, the FDA has received 23 reports of patients who developed oesophageal tumours, including eight deaths.

    Food &Health Skeptic

  • "From this study it cannot be concluded that the alendronate was a causal factor in the development of osteonecrosis," says Khan, who has consulted for drug companies including Merck.

    Science News / Features, Blog Entries, Column Entries, Issues, News Items and Book Reviews

  • In the 150,000-plus cohort of generally healthy postmenopausal women, the researchers found that women who used bisphosphonates, mostly alendronate, which is sold as Fosamax by Merck, had 32 percent fewer cases of invasive breast cancer compared to women who did not use such drugs.

    Newswise: Latest News

  • You can help minimize the loss by getting adequate calcium and vitamin D, and taking a bone-building drug such as alendronate (Fosamax and generic) if you have osteoporosis.

    Q&A: Can anything prevent age-related height loss?

  • You can help minimize the loss by getting adequate calcium and vitamin D, and taking a bone-building drug such as alendronate Fosamax and generic if you have osteoporosis.

    Q&A: Can anything prevent age-related height loss?

  • Drugs, such as alendronate and raloxifene work by decreasing bone resorption.

    The HAQ Frequently Asked Questions by Belisarius (Part II)

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