from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Methotrexate.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Methotrexate

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis


a(mino)- + meth- + pter(oyl), a chemical radical + -in.
(American Heritage® Dictionary of the English Language, Fourth Edition)


  • Freireich finally approached Zubrod with his idea: “I wanted to treat them with full doses of vincristine and amethopterin, combined with the 6-MP and prednisone.”

    The Emperor of All Maladies

  • The next regimen they would try would be a combination of all four drugs: vincristine, amethopterin, mercaptopurine, and prednisone.

    The Emperor of All Maladies


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