Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A substance that closely resembles an essential metabolite and therefore interferes with physiological reactions involving it.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine Any substance that competes with, or inhibits the normal
metabolic process, often by acting as ananalogue of an essentialmetabolite
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun an antineoplastic drug that inhibits the utilization of a metabolite
Etymologies
Sorry, no etymologies found.
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Examples
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Methotrexate is currentlythe only antimetabolite approved by the FDA as a treatment for psoriasis.
Psoriasis Guru » Blog Archive » How Does Methotrexate Work? 2009
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When this process is allowed to proceed normally it is also called “metobolizing,” somethotrexate is also called an “antimetabolite.”
Psoriasis Guru » Blog Archive » How Does Methotrexate Work? 2009
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They prevented rabbits from producing antibody against human serum albumin by treating them for two weeks with the antimetabolite, 6-Mercaptopurine.
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Therefore, acyclovir is transformed into its corresponding nucleotide which is the active antimetabolite and the growth of the virus is inhibited (Figure 3).
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This suggested that other enzymes might also recognize such a side chain as a pentose and that nucleoside analogs of this kind might have antimetabolite properties.
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In 1940, Woods and Fildes (1,2) had put forth the antimetabolite theory to explain the action of sulfonamides on bacteria, suggesting that the sulfonamides interfered with the utilization of a necessary nutrient, para-aminobenzoic acid.
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Methotrexate Toxicity - antimetabolite/antifolate for cancer/autoimmune disease
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Methotrexate is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
PLoS ONE Alerts: New Articles Gang Wu et al. 2010
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Learn about the research that led to the use of the antimetabolite drugs 6-mercaptopurine
The Spark of Yahoo! 2010
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Learn about the research that led to the use of the antimetabolite drugs 6-mercaptopurine
The Spark of Yahoo! 2010
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