Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Any of a class of
chemically engineered oligonucleotides used tosilence endogenous microRNA .
Etymologies
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Examples
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The researchers further manipulated these conditions by inserting an experimental drug into the cells called an antagomir, a synthetic molecule that renders microRNAs inactive and which was designed to act specifically on miR-210.
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When the miR-210 levels were lowered with the antagomir, the E2F3 protein levels rose and the skin-cell growth increased significantly.
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The antagomir was specifically used against a blood vessel growth factor found in human glioblastoma - a type of brain tumor.
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When the mice were given the Isis antagomir, anti-miR-296, the tumor was inhibited from growing and metastasizing into surrounding tissues presumably due to inhibition of growing additional blood supplies or angiogenesis that growing cancer cells normally require in order to proliferate.
qroqqa commented on the word antagomir
The "drug" being tested is an anti-microRNA, or antagomir, designed to inhibit the action of miR-122, a microRNA found almost exclusively in the liver.
—New Scientist, 28 June 2008
July 16, 2008
sionnach commented on the word antagomir
Ooh! Antisense pharmacophores! Slouching towards clinical testing. Ever so slooooowly.
July 16, 2008
sionnach commented on the word antagomir
Of course, there's also Antagomir, the disagreeable sister of Faramir and Boromir,
July 16, 2008