Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun An immunosuppressive agent used especially to prevent organ rejection in kidney transplant recipients.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A particular immunosuppressant.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun an immunosuppressive drug (trade name Imuran) used to prevent rejection of a transplanted organ

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[Probably from az(o)– + thio– + p(u)rine.]

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Examples

  • Prednisone, a form of corticosteroid, and a drug called azathioprine Imuran, which may be given with prednisone, are lifesaving treatments for patients who have moderate to severe cases of autoimmune hepatitis.

    DR. SANJIV CHOPRA’S LIVER BOOK Sanjiv Chopra 2001

  • The most successful compound to emerge from this approach was the 1-methyl-4-nitro-5 imidazolyl derivative, the compound now known as azathioprine (Imuran®).

    Nobel Lecture The Purine Path To Chemotherapy 1988

  • "Our study shows that corticosteroids are very useful in patients with IgA nephropathy, and that the addition of an immunosuppressant drug, such as azathioprine, doesn't increase their benefit," comments Claudio Pozzi, MD (Ospedale E. Bassini, Milan).

    Medindia Health News 2010

  • Other studies have demonstrated that azathioprine, which is in the thiopurine class, can increase the photosensitization of human skin. "

    unknown title 2009

  • Other studies have demonstrated that azathioprine, which is in the thiopurine class, can increase the photosensitization of human skin. "

    PhysOrg.com - latest science and technology news stories 2009

  • The median time to discontinuation of corticosteroid after initiation of 6-mercaptopurine and azathioprine therapy was 8.4 months.

    IBD clinical studies: drug comparisons 2010

  • The patients 'average age at the initiation of treatment with 6-mercaptopurine and azathioprine was 13.8 years.

    IBD clinical studies: drug comparisons 2010

  • They were then analyzed for the development of side effects, the indication to use 6-mercaptopurine and azathioprine and the ability to discontinue corticosteroid use in those patients taking 5-acetylsalicylic acid products who were corticosteroid-dependent or whose disease was refractory to treatment.

    IBD clinical studies: drug comparisons 2010

  • Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger.

    Recent Publications 2010

  • The data support the safety of 6-mercaptopurine and azathioprine use in the treatment of pediatric patients with ulcerative colitis; side effects were minimal and reversible.

    IBD clinical studies: drug comparisons 2010

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