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- noun Plural form of
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Capecchi now made a crucial observation: when the tk gene was injected, copies were integrated in only one or two loci of the host genome, with multiple copies forming head-to-tail concatemers.
He reasoned that such concatemers could only be generated by two mechanisms: either by replication or by homologous recombination.
A series of careful experiments were performed, which unequivocally demonstrated that head-to-tail concatemers were generated by homologous recombination .