d'Azzo

"Our work represents an unexpected and important clue to one of the prominent clinical manifestations of sialidosis patients," d'Azzo said.

unknown title 2009

These findings offer new insight into why bone marrow transplants do not work in humans who lack the neu1 gene, d'Azzo said.

unknown title 2009

"The exciting thing about this work is that it sheds light on two major issues: the cause of sialidosis and the reason for bone marrow transplantation failure in the absence of NEU1," d'Azzo said.

unknown title 2009

"The exciting thing about this work is that it sheds light on two major issues: the cause of sialidosis and the reason for bone marrow transplantation failure in the absence of NEU1," d'Azzo said.

unknown title 2009

These findings offer new insight into why bone marrow transplants do not work in humans who lack the neu1 gene, d'Azzo said.

unknown title 2009

These findings offer new insight into why bone marrow transplants do not work in humans who lack the neu1 gene, d'Azzo said.

unknown title 2009

"The evidence strongly suggests that in children lacking a normal gene for NEU1, disruption of the bone marrow environment causes the exodus of hematopoietic cells from the marrow to the spleen," d'Azzo said.

unknown title 2009

"The discovery is important because it explains why patients with sialidosis have enlarged spleens and suggests that new drugs or gene therapies that target that problem might be an effective therapy," said the paper's senior author, Alessandra d'Azzo, PhD,

unknown title 2009

"Our work represents an unexpected and important clue to one of the prominent clinical manifestations of sialidosis patients," d'Azzo said.

unknown title 2009

"The evidence strongly suggests that in children lacking a normal gene for NEU1, disruption of the bone marrow environment causes the exodus of hematopoietic cells from the marrow to the spleen," d'Azzo said.

unknown title 2009