from Wiktionary, Creative Commons Attribution/Share-Alike License
- v. To lose or reverse differentiation
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- v. lose specialization in form or function
Sorry, no etymologies found.
A Japanese team at Kyoto University has discovered how to reprogram skin cells so that they “dedifferentiate” into the equivalent of an embryonic stem cell.
In other words, a skin cell can dedifferentiate into a stem cell, then regenerate into a muscle cell or another completely different type of cell.
Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium.
Sure enough, Pajcini and Pomerantz found that blocking the expression of both Rb and ARF allowed individual myocytes isolated from mouse muscle to dedifferentiate and begin dividing.
The virus carries dedifferentiate and then gain the ability to differentiate into any type of cell in the body and to indefinitely propagate itself.