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dedifferentiation

Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun The loss or reversal of differentiation.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun the loss of specialization in form or function

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

de- +‎ differentiation

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Examples

  • War, from this point of view, is a precondition for development along new lines of necessity, and the dedifferentiation is the first stage of

    Introduction to the Science of Sociology Robert Ezra Park 1926

  • Another promising approach involves reprogramming adult cells to revert back to an embryonic state, a process known as " dedifferentiation ."

    FAQ: What's Up With Stem Cells? 2005

  • Another promising approach involves reprogramming adult cells to revert back to an embryonic state, a process known as " dedifferentiation ."

    Stem-Cell Finesse Too Grotesque 2005

  • If we consider the Disease Evolution Table, we can see pain results from inflammation, impregnation, degeneration and dedifferentiation phases.

    Dr. Richard Palmquist: Taking the Sting Out of Pain for Your Pet Dr. Richard Palmquist 2011

  • If modern societies, for classical social theory, were characterized by differentiation, for Baudrillard, postmodern societies are characterized by dedifferentiation, the "collapse" of (the power of) distinctions, or implosion.

    Jean Baudrillard Kellner, Douglas 2007

  • The creature's cells can regenerate thanks to built-in time machines that revert cells to early versions of themselves in a process called dedifferentiation.

    Cells That Go Back in Time Kristen Philipkoski 2005

  • But at least one religious leader believes the ability to use dedifferentiation to create human stem cells would eliminate the controversy.

    Cells That Go Back in Time Kristen Philipkoski 2005

  • "For those of us who want to understand what happens in dedifferentiation, our ultimate goal is to be able to form a pool of stem-cell-like cells that would be able to repopulate the organ or tissue you're trying to repair," said Catherine Tsilfidis , a scientist at the Ottawa Health Research Institute who has reproduced Keating's findings, which she describes as "beautiful."

    Cells That Go Back in Time Kristen Philipkoski 2005

  • While the genes were active during maximum dedifferentiation activity, she said, so much is going on in cells after a newt's forelimb is cut off that it's difficult to pick out specific dedifferentiation genes.

    Cells That Go Back in Time Kristen Philipkoski 2005

  • Tsilfidis and her colleagues are now trying to pinpoint which genes are responsible for kick-starting newt dedifferentiation.

    Cells That Go Back in Time Kristen Philipkoski 2005

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