Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb chemistry To remove one or more
methyl groups from a molecule, especially from a biologically active molecule
Etymologies
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Examples
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Drugs that demethylate DNA are under development, but are still some way from approval-and, in any case, interfering with epigenetics, which is a widespread mechanism of gene regulation, is a drastic approach.
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Drugs that demethylate DNA are under development, but are still some way from approval-and, in any case, interfering with epigenetics, which is a widespread mechanism of gene regulation, is a drastic approach.
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Drugs that demethylate DNA are under development, but are still some way from approval-and, in any case, interfering with epigenetics, which is a widespread mechanism of gene regulation, is a drastic approach.
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These results indicate that ceKDM7A is recruited to the promoter to demethylate H3K9me2 and
Naturejobs - All Jobs Hanqing Lin 2010
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As it is unlikely that HERV-K is able to demethylate its proviruses, the loss of methylation must be the result of genetic changes in the cell, e.g., a loss of DNMT1 activity.
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Studies using cow and rabbit eggs clearly suggest that DNA methylation / demethylation of the donor DNA occurs in a species-specific way, and that the eggs might lack the ability to demethylate repetitive sequences from other species.
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This concept is supported by cell line experiments demonstrating that BORIS expression by itself is sufficient to simultaneously demethylate and activate the transcription of these genes.
PLoS ONE Alerts: New Articles Ian M. Smith et al. 2009
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2006, Zhang showed that Jhdm2a was able to demethylate, or remove, a methyl group from one of four histone proteins bound to all genes.
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