from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Hard to work with; stubborn.
  • adj. Difficult.

from the GNU version of the Collaborative International Dictionary of English

  • adj. Difficult; hard to manage; stubborn.

from The Century Dictionary and Cyclopedia

  • Difficult; hard; arduous; perplexing.
  • Reluctant; scrupulous.


from Wiktionary, Creative Commons Attribution/Share-Alike License

From late Old French difficile, from Latin difficilis, from dis- + facilis ("easy").


  • And there's actually a very specific experiment I'd like you to discuss, if you could, and that had to do with a patient who had a C. difficile, which is a bacterial infection that causes such extreme diarrhea that some elderly people die as a result.

    Bacterial Bonanza: Microbes Keep Us Alive

  • The study examined hospital patients infected with the drug-resistant bacteria Clostridium difficile, which is infamous for causing diarrhea in hospitalized patients and responsible for more deaths in the United States than all other intestinal infections combined.

    Yahoo! News: Business - Opinion

  • Clostridium difficile, which is especially lethal to the elderly, suggest it prevents recurrence far better than currently used medications.

    Yahoo! News: Business - Opinion

  • Food and Drug Administration next week for a clearance to market its Illumigene molecular test for C. difficile, which is currently undergoing a clinical trial.

    Los Angeles Business News - Local Los Angeles News | Los Angeles Business from bizjournals

  • "The BSM-2000's detection method for detecting anthrax can also be used for detecting C. difficile, which is also a spore forming bacteria," said Mr. Amir Ettehadieh, UNDT's Director of Research and Development.


  • We now face the opposite problem of being unable to contain the growth and spread of the same bacterium, now called Clostridium difficile, which is a frequent cause of infectious colitis, usually occurring as a complication of antibiotic therapy, in elderly hospitalized patients.

    Medlogs - Recent stories

  • Optimer Pharmaceuticals is working on several potential new drugs including fidaxomicin, a treatment for the bacterial infection Clostridium difficile which is often contracted in hospitals.

    Fore, right!

  • Medizone's CEO Edwin Marshall added, "Following the impressive results recently announced for MRSA, we immediately began to assess the capability of AsepticSure (TM) using the same updated technology with the spore forming bacteria C difficile, which is ubiquitous within hospitals and chronic care centers.


  • 'difficile', though Hodder had never found her so.

    The Inside of the Cup — Complete

  • Partout où le poids de la tradition est importante il y est difficile d'impulser le progrès tel le conçoit le monde contemporain.

    Global Voices in English » Obama’s Ghana Speech Underwhelms


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