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- n. The ability of a portion of a genome to be targeted by a drug, especially by a small molecule drug
Sorry, no etymologies found.
Potential areas of study for the future are proposed, which include a new classification system consisting of specific families and the identification of PPI targets with high druggability potential based on key descriptors of the interaction.
However, it should be noted that this type of analysis represents an initial step, since the druggability of each site requires evaluation by medicinal chemists
Coleman RG, Smyth KT, Cao Q, Soulard P, et al. (2007) Structure-based maximal affinity model predicts small-molecule druggability.
2P2I database stores structural information about PPIs with known inhibitors and provides a useful tool for biologists to assess the potential druggability of their interfaces.