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eating mouldy peanuts


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  • aflatoxin > p53 mutation > (liver) cancer

    November 21, 2008

  • Mouldy peanuts give you liver cancer?

    November 21, 2008

  • Aflatoxins are among the most carcinogenic substances known. When the liver is exposed to them, necrosis, cirrhosis, and/or liver cancer can result--though I don't know the whole process, not being a medical type. :-)

    I know this is a problem with peanuts, having worked at the pb cup factory years ago, but it affects other crop types as well.

    November 21, 2008

  • *rethinks hanging out at Five Guys*

    November 21, 2008

  • I think everyone's pretty careful about screening for aflatoxins, c_b. I mean, who wants to be the one who poisons people with moldy peanuts?

    November 21, 2008

  • also note that when genetic tests are done on tumours, about half of them have p53 mutations (this statistic cited by the prof in a course I took in cell bio).

    November 22, 2008

  • What chemicals are produced by mouldy peanuts?

    February 22, 2009

  • IIRC p53 is one of the normal repair systems within cells, so that it can be considered a kind of braking system against uncontrolled growth. p53 mutations can interfere with this natural braking mechanism. Though, generally speaking this alone will not be sufficient to induce cancerous growth, when combined with the breakdown of other braking mechanisms, such as apoptosis, and the upregulation of certain growth signaling factors (either through genetic bad luck, or mutation resulting from environmental factors), trouble can result.

    So, which is worse - moldy peanuts and liver cancer, or moldy grain and being condemned as a witch?

    February 22, 2009

  • Well, I'd say the moldy peanuts. In order to get accused a witch regarding moldy grain, don't you have to ... er... can you get it from *eating* the grain?

    February 24, 2009

  • You don't have to even eat the grain, if everyone else around you does. Cogitot ergot sum witchum.

    February 24, 2009

  • Well, I meant that... don't you have to do something else with the moldy grain, besides eat it?

    February 24, 2009