from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleic acids in the interior of a DNA or RNA molecule.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any enzyme which catalyzes the cleavage of nucleic acids so as to produce variously sized fragments.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes


Sorry, no etymologies found.


  • Church, “The cleavage site of the restriction endonuclease Ava II,” Nucleic Acids Research 5 1978, 2313–2319.

    The $1,000 Genome

  • AP endonuclease recognizes this site and nicks the damaged DNA on the 5 'side (upstream) of the AP site creating a free 3'-OH.

    Another Protozoan and Front-Loading

  • Subsequently, it has been shown that RISC contains at least one member of the argonaute protein family, which is likely to act as an endonuclease and cut the mRNA (nowadays often referred to as the Slicer function).

    Advanced Information: The 2006 Nobel Prize in Physiology or Medicine

  • Double-stranded RNA is cut into short pieces (siRNA) by the endonuclease Dicer.

    Advanced Information: The 2006 Nobel Prize in Physiology or Medicine

  • "Cleavage of DNA by R1 restriction endonuclease generates cohesive ends," Proc.

    Asilomar and Recombinant DNA

  • This was an exciting period in the molecular biology of adenovirus with the discoveries (a) that only one specific fragment of the genome, the E1 region, was responsible for oncogenic transformation; (b) that restriction endonuclease length polymorphism could be utilized to generate genetic maps; (c) the mapping of specific genes on the viral genome; and (d) generation of a viral map of sequences expressed as stable RNAs.

    Phillip A. Sharp - Autobiography

  • Ulf, I, and others generated the first restriction endonuclease maps of this virus, and Dr.S. Jane Flint and I began to analyze the regions of the genome expressed as mRNAs in both productively infected cells and in adenovirus transformed cells.

    Phillip A. Sharp - Autobiography

  • Meselson's laboratory at Harvard University to study a DNA endonuclease involved in the replication and recombination of T4

    Sidney Altman - Autobiography

  • Hamilton Smith telling me about the restriction endonuclease he had discovered in Hemophilus influenzae aroused my interest in the possibility of using restriction enzymes to dissect the genomes of DNA tumor viruses.

    Daniel Nathans - Autobiography

  • The chemistry of water activated by a magnesium ion is central to the function of the DNA repair proteins, apurinic/apyrimidic endonuclease 1 (Ape1) and polymerase A (Pol A).

    Signs of the Times


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