Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The univalent radical derived from farnesol

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

farnesol +‎ -yl. Thus ultimately from Farnese via Acacia farnesiana (the sweet acacia tree) and its namesake Odoardo Cardinal Farnese.

Examples

  • The quinone moiety and farnesyl chain are recognized by P64, F107, and other indicated residues via hydrophobic interactions. doi: 10.1371/journal. pone.0010760.g006

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  • Green spheres represent magnesium cations in the active site with a docked farnesyl-diphosphate (red stick representation).

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  • (F) Active site of UBIAD1 with a menaquinone-farnesyl derivative that optimally docks to the protein.

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  • C1-atom of the farnesyl moiety is 3.8 Å (red dashed line).

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  • David E, Sun SY, Waller EK, Chen J, Khuri FR, et al. (2005) The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

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  • Also, the addition of phenyl function in the side chain of BPs rendered the catalytic pocket of geranyl and / or farnesyl synthase enzymes of the mevalonate pathway more accessible

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  • N-BPs, such as zoledronate, acted on the mevalonate pathway inhibiting the farnesyl diphosphate synthase (FPP) thereby depleting the cells of the farnesyl (FPP) or geranylgeranyl (GGPP) diphosphate isoprenoids

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  • Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, et al. (2006) Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.

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  • In parallel, recently crystallographic and computational investigation revealed that the presence of phenyl ring in the side chain permitted non N-BPs to interact with farnesyl enzyme

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  • The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyl-transferase.

    BioMed Central - Latest articles

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