Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A filament-associated protein that binds to keratin fibres in epithelial cells

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. the main protein of the keratohyalin granules

Etymologies

Sorry, no etymologies found.

Examples

  • Later on, an approved gene name filaggrin-2 (gene symbol FLG2) was suggested by the HUGO / GDB Nomenclature Committee.

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  • We provide evidences that like filaggrin, FLG2 is initially expressed by upper granular cells, proteolytically processed and deposited in the stratum granulosum and stratum corneum (SC) layers of normal epidermis.

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  • Palmer CNA, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.

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  • The liberated filaggrin is an essential component of the SC that participates in the aggregation of keratin filaments into bundles and promote the flattened shape of dead-cell remnants

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  • By using these tandem repeats as queries in BLAST homolog searches against the human protein database, the most positive hit homologous to each A-type repeat was from repetitive domains of hornerin (50-77\% identity) whereas that homologous to each B-type repeat was from filaggrin units (28-39\% identity) (data not shown).

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  • Recent genetic studies have shown that mutations within the gene encoding the SFTP filaggrin cause ichthyosis vulgaris and are major predisposing factors for atopic dermatitis.

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  • FLG gene causing ichthyosis vulgaris, filaggrin units represent major risk factors for atopic dermatitis (AD) and secondary allergic diseases

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  • McKinley-Grant LJ, Idler WW, Bernstein IA, Parry DA, Cannizzaro L, et al. (1989) Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.

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  • As a vital component of healthy skin, filaggrin is also a precursor of natural moisturizing factors.

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  • Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin.

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Comments

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  • In 2006, a mutation in the gene for the protein filaggrin – which keeps foreign substances out of the skin – was shown to increase the risk of eczema.

    New Scientist, 28 June 2008

    July 14, 2008