from The Century Dictionary.

  • noun Same as hypertonia.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun the condition of being hypertonic

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun (of a solution) the extent to which a solution has a higher osmotic pressure than some other
  • noun (of muscular tissue) the state of being hypertonic


from Wiktionary, Creative Commons Attribution/Share-Alike License

hypertonic +‎ -ity


  • In addition to muscle weakness, many children have spasticity or hypertonicity in the muscles of the weaker side.

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  • They list such benefits as alleviating pain and reducing inflammation; reducing hypertonicity of muscles; improving joint and muscle function; and reducing and relieving skin irritation, cutaneous lesions with neurodermatitis and psoriasis.

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  • Microarray profiling of wild type worms exposed to non-lethal hypertonicity identified a suite of genes that were also regulated by infection.

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  • We also show that pathologic hypertonicity levels, as occurring in plasma of patients and animal models of osmoregulatory disorders, inhibited the induction of cyclins and aurora B kinase in response to T cell receptor stimulation in fresh NFAT5

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  • Effect of hypertonicity on cyclin induction by mitogens or T cell receptor activation in NFAT5 − / − T cells.

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  • Mutin M, Woo SK, Kwon HM, Tappaz ML (2004) Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain.

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  • We show that hypertonicity triggered an early, NFAT5-independent, genotoxic stress-like response with induction of p53, p21 and GADD45, downregulation of cyclins, and cell cycle arrest.

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  • We were interested in analyzing how the deficiency of NFAT5 in proliferating cells affected hypertonicity-regulated processes such as the induction of genotoxic stress-like responses and the cell cycle.

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  • This interpretation is consistent with the finding that cells lacking the chaperones Hsp70 and Hspa4l / Osp94, whose induction by hypertonicity is NFAT5-dependent, have defects similar to those of NFAT5

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  • Our results show that hypertonicity elicited an early, NFAT5-independent, genotoxic stress response and cell cycle arrest in proliferating lymphocytes, which was followed by an NFAT5-dependent phase in which cells induced osmoprotective gene products, downregulated genotoxic stress markers and reactivated the cell cycle.

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