from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun An organic crystalline base, C3H4N2, that is an inhibitor of histamine.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A
heterocyclic organic compoundcontaining two nitrogenatoms separated by a carbonatom in a five-membered ring, called 1,3-diazole in IUPAC nomenclature.
- noun organic chemistry A group of compounds containing that
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun an organic base C3H4N2; a histamine inhibitor
from The American Heritage® Dictionary of the English Language, 4th Edition
Free imidazole compounds in white and dark muscles of migratory marine fish.
The dark blue copper ion is bonded in a cavity between two imidazole groups (the five-membered rings) and two yellow sulphur atoms.
The experimental drug, BW - 322, the imidazole derivative of 6-MP, seemed to have the best therapeutic index.
Cooperating with the I.G. Farbenindustry, which supplied the precious raw material for the work, he was able to prove that not an imidazole-ring (as suggested by Jansen and Donath), but a thiazole - and a pyrimidine-ring are present in vitamin
The production of imidazole derivatives as a result of this reaction induced him to demonstrate the presence of a prototype of the imidazole ring in proteins.
Another rich field of investigation from biological viewpoint was that of imidazole derivatives.
It was also his interest in the imidazole derivatives that prompted him to examine the structure of the antineuritic vitamin.
This in turn led to his demonstration that histidine, a building-stone of proteins, is an imidazole alanine, and to his discovery of histamine
Bound proteins were eluted by adding 100 µL of Tris-Cl pH 8.0, 300 mM NaCl, 250 mM imidazole and collecting the flow through.
Remaining unbound proteins were removed by washing the nickel resin 4X with 200 µL of 50 mM Tris-Cl pH 8.0, 300 mM NaCl, and 50 mM imidazole.
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