Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun An organic crystalline base, C3H4N2, that is an inhibitor of histamine.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun organic chemistry A heterocyclic organic compound containing two nitrogen atoms separated by a carbon atom in a five-membered ring, called 1,3-diazole in IUPAC nomenclature.
  • noun organic chemistry A group of compounds containing that structure.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun an organic base C3H4N2; a histamine inhibitor

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[imid(e) + azole.]

Examples

  • Free imidazole compounds in white and dark muscles of migratory marine fish.

    Potential impacts of direct mechanisms of climate change on human health in the Arctic

  • The dark blue copper ion is bonded in a cavity between two imidazole groups (the five-membered rings) and two yellow sulphur atoms.

    The Nobel Prize in Chemistry 1992

  • The experimental drug, BW - 322, the imidazole derivative of 6-MP, seemed to have the best therapeutic index.

    Joseph E. Murray - Nobel Lecture

  • Cooperating with the I.G. Farbenindustry, which supplied the precious raw material for the work, he was able to prove that not an imidazole-ring (as suggested by Jansen and Donath), but a thiazole - and a pyrimidine-ring are present in vitamin

    Adolf Windaus - Biography

  • The production of imidazole derivatives as a result of this reaction induced him to demonstrate the presence of a prototype of the imidazole ring in proteins.

    Adolf Windaus - Biography

  • Another rich field of investigation from biological viewpoint was that of imidazole derivatives.

    Adolf Windaus - Biography

  • It was also his interest in the imidazole derivatives that prompted him to examine the structure of the antineuritic vitamin.

    Adolf Windaus - Biography

  • This in turn led to his demonstration that histidine, a building-stone of proteins, is an imidazole alanine, and to his discovery of histamine

    Adolf Windaus - Biography

  • Bound proteins were eluted by adding 100 µL of Tris-Cl pH 8.0, 300 mM NaCl, 250 mM imidazole and collecting the flow through.

    PLoS ONE Alerts: New Articles

  • Remaining unbound proteins were removed by washing the nickel resin 4X with 200 µL of 50 mM Tris-Cl pH 8.0, 300 mM NaCl, and 50 mM imidazole.

    PLoS ONE Alerts: New Articles

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