Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Any of a group of enzymes that catalyze the formation of double bonds by removing chemical groups from a substrate without hydrolysis or catalyze the addition of chemical groups to double bonds.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of many classes of enzyme that catalyze the breaking of a specific form of bond

Etymologies

Greek lūein, to loosen; see leu- in Indo-European roots + -ase.
(American Heritage® Dictionary of the English Language, Fourth Edition)

Examples

  • Garcinia Cambogia: is a natural form of Hydroxcitric acid (HCA) which can inhibit an enzyme in cells, citrate lyase, which is needed for the conversion of carbohydrates into fat.

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  • HCA has been thought to suppress enzymatic activity of citrate lyase which is responsible for lipogenesis and fatty acid biosynthesis.

    Scientific Blogging

  • Previously reported Phase 2a results of LX2931, an inhibitor of sphingosine-1-phosphate lyase, demonstrated a favorable safety profile at all doses tested and suggested that rheumatoid arthritis patients treated with 150 mg of LX2931 once daily showed improvement in the primary efficacy endpoint of the study, the percentage of patients achieving an American College of Rheumatology 20 ACR20 response at week 12.

  • Moreover, Bio Shape works metabolically through Garcinia Cambogia, which inhibits an enzyme called citrate lyase to prevent excess fat.

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  • Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase II clinical development for the treatment of PKU; GALNS

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  • It promotes fat oxidation inhibiting ATP-citrate lyase and lowers the levels of leptin in obese subjects.

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  • Pereira JP, Matloubian M, Xu Y, Huang Y, et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.

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  • We show by using cell extracts that Ku is essential for the efficient removal of AP sites near double-strand breaks and, consistent with this result, that joining of such breaks is specifically decreased in cells complemented with a lyase-attenuated Ku mutant.

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  • GALNS (N-acetylgalactosamine 6-sulfatase), which is currently in clinical development for the treatment of MPS IVA; PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase II clinical development for the treatment of PKU and BMN 195, which is currently in Phase I clinical development for the treatment of Duchenne Muscular Dystrophy.

    RedOrbit News - Technology

  • Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl) - induces differentiation of mouse C2C12 myoblasts even in the presence of mitogens.

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