Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun A toxic white crystalline compound, C16H15Cl3O2, similar to DDT, and used as an insecticide.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun organic chemistry A synthetic organochlorine used as an insecticide.

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[meth– + oxy– + (tri)chlor(oethane), a chemical compound used in pesticides.]

Examples

  • In this study, the authors write: It is worthwhile noting that the lower dose of methoxychlor tested (3 mg/pellet, or approximately 1.2 mg/kg/day) is 4-fold lower than the NOEL used by the U.S. Environmental Protection Agency (EPA) in developing an oral reference dose for methoxychlor.

    The Autoimmune Epidemic

  • In this study, the authors write: It is worthwhile noting that the lower dose of methoxychlor tested (3 mg/pellet, or approximately 1.2 mg/kg/day) is 4-fold lower than the NOEL used by the U.S. Environmental Protection Agency (EPA) in developing an oral reference dose for methoxychlor.

    The Autoimmune Epidemic

  • This suggests that an effect on autoimmunity might be a sensitive toxic end point an effect that occurs at doses lower than other adverse effects for methoxychlor, and therefore of particular interest for risk assessment.

    The Autoimmune Epidemic

  • This suggests, say the authors, that the commonly used pesticide methoxychlor might stimulate autoimmunity at a much lower dose than doses necessary to cause other adverse health effects, and is “therefore of particular interest for risk assessment.”

    The Autoimmune Epidemic

  • Immunologists, meanwhile, are trying to ascertain what happens to the immune systems of lab mice when they expose them to organochlorine pesticides such as DDT and methoxychlor, the latter having been manufactured as a safer replacement for DDT and now being used widely on food crops, home gardens, and as flea and tick control on pets.

    The Autoimmune Epidemic

  • Immunologists, meanwhile, are trying to ascertain what happens to the immune systems of lab mice when they expose them to organochlorine pesticides such as DDT and methoxychlor, the latter having been manufactured as a safer replacement for DDT and now being used widely on food crops, home gardens, and as flea and tick control on pets.

    The Autoimmune Epidemic

  • This suggests, say the authors, that the commonly used pesticide methoxychlor might stimulate autoimmunity at a much lower dose than doses necessary to cause other adverse health effects, and is “therefore of particular interest for risk assessment.”

    The Autoimmune Epidemic

  • This suggests that an effect on autoimmunity might be a sensitive toxic end point an effect that occurs at doses lower than other adverse effects for methoxychlor, and therefore of particular interest for risk assessment.

    The Autoimmune Epidemic

  • In a startling experiment published in 2005, scientist Michael Skinner exposed a pregnant rat to two commonly used industrial chemicals: vinclozolin, a fungicide, and methoxychlor, an insecticide.

    Origins

  • Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozalin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induces decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility in nearly all males of all subsequent generations examined.

    Dan Agin: Plastic Bottles, Poison, and Endocrine Disruptors

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