myristoylation love

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from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The attachment of a myristoyl group to a protein or polypeptide


From myristoyl + -ation. (Wiktionary)


  • N-myristoylation (catalyzed by an enzyme abbreviated as NMT) which is a process that's important for membrane targeting and trafficking.

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  • N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT).

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  • The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N-terminus of mCherry to generate a plasma membrane marker

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  • Therefore, we generated the activating mutation by addition of the avian src myristoylation sequence (MGSSKSKPK) at the N-terminus of the wild type of murine

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  • The activating mutation was generated by addition of the avian src myristoylation sequence (MGSSKSKPK) at the N-terminus. pCI-neo, which contains a chimeric intron, was ordered from Promega (Promega, Madison, WI). pMigR, which contains an internal ribosome entry site

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  • This positioning of serine, as well as the coincidental fact that the amino terminal residue of our substrate is glycine, is strongly reminiscent of the consensus sequence for N-terminal glycine myristoylation.

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  • This could consist either of zinc-dependent proteolytic activation of ERAT, or a zinc-dependent proteolytic processing of the substrate (for example, to expose a putative acylation consensus sequence, similar to that seen for myristoylation).

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  • By western blot with Nkd1 antibodies we are unable to distinguish wild-type from mutant Nkd1 in cell line HCT15, which harbors Nkd proteins are membrane-associated, the mammalian Nkds by virtue of N-terminal myristoylation

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  • NKD1-mutant cell lines tested, we hypothesize that the mutant Nkd1 proteins - each of which retains multiple functional motifs (N-terminal myristoylation, EFX, and 30 aa motifs) - activate Wnt signaling in vivo, perhaps analogous to the manner in which Apc proteins truncated near the MCR activate Wnt signaling

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  • Science/Tech/Health/Single Vector System for Efficient N-myristoylation of Recombinant Proteins in E. coli

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