Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The attachment of a
myristoyl group to aprotein orpolypeptide
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT).
Elites TV PLoS ONE 2010
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The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N-terminus of mCherry to generate a plasma membrane marker
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The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N-terminus of mCherry to generate a plasma membrane marker
PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010
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N-myristoylation (catalyzed by an enzyme abbreviated as NMT) which is a process that's important for membrane targeting and trafficking.
In the Pipeline 2010
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The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N-terminus of mCherry to generate a plasma membrane marker
PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010
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The myristoylation/palmitylation motif from the Lck tyrosine kinase was attached to the N-terminus of mCherry to generate a plasma membrane marker
PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010
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The activating mutation was generated by addition of the avian src myristoylation sequence (MGSSKSKPK) at the N-terminus. pCI-neo, which contains a chimeric intron, was ordered from Promega (Promega, Madison, WI). pMigR, which contains an internal ribosome entry site
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This positioning of serine, as well as the coincidental fact that the amino terminal residue of our substrate is glycine, is strongly reminiscent of the consensus sequence for N-terminal glycine myristoylation.
PLoS ONE Alerts: New Articles Akihiko Ozawa et al. 2009
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This could consist either of zinc-dependent proteolytic activation of ERAT, or a zinc-dependent proteolytic processing of the substrate (for example, to expose a putative acylation consensus sequence, similar to that seen for myristoylation).
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Therefore, we generated the activating mutation by addition of the avian src myristoylation sequence (MGSSKSKPK) at the N-terminus of the wild type of murine
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