Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun That which is not a
secretor .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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[17] Similarly, Lewis negative or nonsecretor status was significantly associated with lower lung function, and higher prevalence of wheezing and asthma, in blood group O adults.
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[18] The association between blood group O / nonsecretor genotype and asthma has also been demonstrated in children.
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To investigate the effect of blood group alleles (ABO genotype, nonsecretor phenotype, and FUT3 genotypes producing Lewis negative phenotypes) on CF lung severity risk, we performed multiple logistic regression analyses to predict severity status.
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The study found no correlation between secretor status and the clinical variables examined; however, it may have been significantly underpowered to detect a difference with only 17 patients in the nonsecretor group.
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To investigate the effect of blood group alleles (ABO genotype, nonsecretor phenotype, and FUT3 genotypes producing Lewis negative phenotypes) on CF lung severity risk, we performed multiple logistic regression analyses to predict severity status.
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FUT2 ( "secretor / nonsecretor") alleles for SNP G428A (rs601338) were successfully determined in
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Bias WB, Chase GA, Diamond EL, Graves CG, et al. (1980) Is ABH nonsecretor status a risk factor for obstructive lung disease?
vendingmachine commented on the word nonsecretor
"A nonsecretor is someone, who through their own genetics, carries a gene which inhibits them from secreting their ABO blood type in their secretions. By secretions we mean saliva, semen, etc. Eighty-five percent of the population are secretors, so nonsecretors are in a minority. If you are a secretor, you express more of your blood type in your body. In the case of type A, where many things can mimick this blood type, being a secretor means that the "grass is taller" so bad guys can sometimes hide better. Being a nonsecretor implies that some design elements of their immune system are evolutionarily older. Secretors tend to wall out bad guys and kill them outside the body. Nonsecretors prefer to let them in and kill them within the blood stream. This is not always a wise way of doing things, and nonsecretors do suffer from a variety of conditions known to result from the systemic spread of an infection, including mitral valve problems and kidney disease. Nonsecretors should probably get antibiotic therapy prior to bloody or invasive dental work. I usually don't make this recommendation to secretors. Perhaps what is most interesting about being a nonsecretor, is that apparently the gene is cross-linked to otherwise unrelated genes, such as the yet undiscovered gene for alcoholism. We know this because in two very large, well done studies, there is a distinct link between nonsecretors and family histories of alcoholism. What makes the association even more bizarre is that nonsecretors have also been shown to be the subset of people who get the cardiovascular benefits of wine consumption." --Ask Dr. D'Adamo
June 19, 2015