from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. any of a class of proteins, rich in arginine, found in the sperm of fish; used medicinally to control the action of insulin
from The Century Dictionary and Cyclopedia
- n. A member of a group which comprises the simplest albumins known to occur in the animal body.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
Sorry, no etymologies found.
One test was normal, but the other two were given another drug, protamine sulfate, that reverses the effects of heparin.
Langberg also said two patients were given protamine sulfate, a drug that reverses the effects of heparin.
After two years in their laboratory, during which time I studied the interaction of protamine with rabbit muscle phosphorylase, I became so enamored with biochemistry that
Earlier it was generally accepted that guanine and other similar substances originated from the protein molecule and Miescher thought that these bodies perhaps arose from protamine, while Piccard put forward the idea that
LMWP peptides can be produced quickly, easily, and inexpensively in large amounts from the protein protamine.
Thus, his team has developed a short peptide, the low molecular weight protamine
Morales CR, Kwon YK, Hecht NB (1991) Cytoplasmic localization during storage and translation of the mRNAs of transition protein 1 and protamine 1, two translationally regulated transcripts of the mammalian testis.
Giorgini F, Davies HG, Braun RE (2001) MSY2 and MSY4 bind a conserved sequence in the 3′ untranslated region of protamine 1 mRNA in vitro and in vivo.
In 1946, Nordisk was able to form crystals of protamine and insulin and marketed it in 1950 as NPH insulin.
Pre-clinical and clinical data suggest many potential safety and other advantages over protamine, as well as a unique opportunity as the first reversing agent for LMWHs.