ribosomal

When a messenger RNA has found a ribosome, it is anchored between the ribosomal subunits, ready to be translated to the chain of amino acids which, properly folded, becomes active protein.

The Nobel Prize in Chemistry 2009 - Presentation Speech

Ada Yonath's pioneering work during the 1980s laid the foundation for determination of high-resolution ribosomal structures with crystallographic techniques.

The Nobel Prize in Chemistry 2009 - Presentation Speech

In 1998 Thomas Steitz solved the so called phase problem for the large ribosomal subunit and could thereby determine the first ribosomal crystal structure.

The Nobel Prize in Chemistry 2009 - Presentation Speech

Ramakrishnan, Steitz and Yonath determined high resolution structures of ribosomal subunits in complex with antibiotic drugs, leading to atomic level understanding of how these drugs inhibit ribosome function and how drug target resistance may evolve.

The Nobel Prize in Chemistry 2009 - Presentation Speech

Thomas Steitz's high resolution structures of the large ribosomal subunit in functional complexes led to atomic level understanding of how formation of peptide bonds between amino acids is catalysed on the ribosome.

The Nobel Prize in Chemistry 2009 - Presentation Speech

Venkatraman Ramakrishnan's crystal structures of the small ribosomal subunit in functional complexes led to atomic level understanding of how ribosome-assisted reading of the genetic code can be so accurate that virtually all proteins are made error free in accordance with the blueprints of their genes.

The Nobel Prize in Chemistry 2009 - Presentation Speech

In the year 2000, all three Laureates presented high resolution structures of ribosomal subunits, Steitz of the large, Ramakrishnan and Yonath of the small ribosomal subunit.

The Nobel Prize in Chemistry 2009 - Presentation Speech

This assembly maps involves 15 universal small subunit ribosomal proteins, and of these 15, ten have a moonlighting role (we shall explore several of these functions at a future date).

2009 June - Telic Thoughts

"Molecular signatures of ribosomal evolution," PNAS 105 (2008): 13953-58.

A Disclaimer for Behe?

One can agree that LGT will likely not interfere with a robust phylogeny for primates that indeed recreates ancient splittings of their populations, without buying in to the notion that the supposed sisterhood of Thermotogales and Aquificales [two bacterial phyla — OT] revealed by a small subset of their shared ribosomal protein genes reflects an even remotely similar evolutionary process.

A Disclaimer for Behe?