Definitions
from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A lymphocyte that derives from the thymus and is the precursor of a T cell.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. a lymphocyte, produced in the thymus, that develops into a T cell
Etymologies
Examples
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Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation.
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Because thymic tumors can support thymocyte development, aberrant T-cell generation has been suggested as a cause.
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The development of CMV CNS disease is associated with risk factors (T-cell depletion, anti-thymocyte globulin, umbilical cord blood transplantation) that cause severe and protracted T-cell immunodeficiency (8 of 11 cases), a history of recurrent CMV viremia treated with multiple courses of preemptive ganciclovir or foscarnet therapy (11 of 11 cases), and ganciclovir-resistant CMV infection (11 of 11 cases).
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In addition, FACS analysis of thymocytes derived from TetO-Dkk1 and K5rtTA-ST mice following 4 weeks of Dox feeding using antibodies against CD4, CD8, TCRβ, CD25 and CD44 was used to assess differences in thymocyte subset frequency.
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Carter C, Gimenez-Conti IB, Richie ER (2002) Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus.
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Regulation of Wnt signaling has also been shown to impact both early thymocyte and thymic epithelial development.
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Following 4 weeks of Dox feeding, FACS analysis of thymocytes derived from either male or female TetO-Dkk1 mice showed no changes in the frequency of individual thymocyte subsets.
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A key role for the Wnt signaling cascade in controlling thymocyte cellularity and differentiation is apparent from studies using Tcf-1/LEF-1 knockout mice, as well as a number of complementary gain-of-function and loss-of-function studies
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Meeldijk J, Moerer P, Jay P, van de Weerdt BC, et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.
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To examine if DKK1-mediated inhibition of canonical Wnt signaling in TECs, impacted T cell development, total thymocyte numbers were counted.
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